2021 Drug Design(Fudan University) 最新满分章节测试答案

文章目录[隐藏]

Chapter 1 Introduction Unit one Test
Chapter 2 Drug Targets and Theories Unit two Test
Chapter 3 Drug Design Based on Structure (Part 1) Unit three Test
Chapter Three Drug Design Based on Structure (Part 2) Unit Three part 2 Test
Chapter 4 Lead Compound Property Design Optimization (Part 1) Unit 4 PART 1 TEST
Chapter 4 Lead Compound Property Design Optimization (Part 2) Unit 4 PART 2 TEST
Chapter 5 Computer Aided Drug Design Experiment (Part 2) Unit 5 TEST

本答案对应课程为:点我自动跳转查看
本课程起止时间为:2021-03-01到2021-06-27
本篇答案更新状态:已完结

Chapter 1 Introduction Unit one Test

1、问题:Modern innovative drug discovery is a research process from genes to drugs. It has gone through three stages, which of the following is not?
选项：
A:Discovery of new targets
B:Discovery of lead compounds
C:Drug development
D:Consistency evaluation
答案: 【Consistency evaluation】

2、问题:How many years does it take to discover modern innovative drugs?
选项：
A:2-3 years
B:5-8 years
C:12-15 years
D:20-30 years
答案: 【12-15 years】

3、问题:The concept of structural biology inspired by the structure of the target promoted the discovery of __, which is the First of Class drug of Puri series antihypertensive drugs and the prototype of drug design based on ____.
选项：
A:Enalapril, ligand pharmacophore
B:Captopril structure
C:Enalapril, structure
D:Captopril, ligand pharmacophore
答案: 【Captopril structure】

4、问题:The main methods of drug design include ()
选项：
A:Drug design based on the interaction between the target and the drug
B:Computer aided drug design
C:Drug design based on early ADME/T evaluation
D:All of them
答案: 【All of them】

5、问题:Modern drug design ideas based on the research of disease mechanisms, gene defects and other signal pathways discovered by _____ as the core reflect the new progress and new trends in the contemporary drug discovery field.
选项：
A:Random screening
B:Combinatorial chemistry
C:High-throughput screening
D:Target
答案: 【Target】

6、问题:___ is the main way of classic drug discovery.
选项：
A:High-throughput screening
B:Random screening
C:Target-based screening
D:Pharmacophore model screening
答案: 【Random screening】

7、问题:The target is ______ with a specific function in the body, and the drug exerts its efficacy by combining with it.
选项：
A:organ
B:organization
C:biomacromolecule
D:cell
答案: 【biomacromolecule】

8、问题:Which of the following is not a requirement for an effective drug?
选项：
A:Interact with target
B:Binding to plasma proteins
C:Maintain an appropriate concentration at the target
D:Have enough time to interact with the target
答案: 【Binding to plasma proteins】

9、问题:Which of the following does not fall into the category of drug-receptor interaction theory?
选项：
A:Lipinski rule
B:Lock and key theory
C:Molecular recognition
D:Induced fit theory
答案: 【Lipinski rule】

10、问题:What are the two classifications of structure-based drug design?
选项：
A:Direct drug design, indirect drug design
B:Fragment drug design, drug property design
C:Direct drug design, fragment drug design
D:Direct drug design, drug property design
答案: 【Direct drug design, indirect drug design】

11、问题:Indirect drug design is based on the design of the three-dimensional structure of ____.
选项：
A:Receptor
B:Protein
C:Compound
D:Ligand
答案: 【Ligand】

12、问题:What are the ways to discover lead compounds?
选项：
A:Screening approach
B:Structure-based drug design
C:Property-based drug design
D:All of them
答案: 【All of them】

Chapter 2 Drug Targets and Theories Unit two Test

1、问题:Which of the following scientists proposed the idea of side chain that is the prototype of modern drug target theory?
选项：
A:Gerhard Domagk who invented Prontosil
B:Paul Janssen who invented haloperidol and fentanyl
C:Paul Ehrlich who invented Ars vannamei
D:James Black who invented propranolol and cimetidine
答案: 【Paul Ehrlich who invented Ars vannamei】

2、问题:Which of the following technologies is not a target structural biology research technology?
选项：
A:Cryo-EM technology
B:NMR technology
C:X-ray single crystal diffraction technique
D:Computer tomography
答案: 【Computer tomography】

3、问题:The following are not drug targets
选项：
A:Dopamine receptor
B:Serotonin reuptake transporter
C:Amoeba
D:Tetrahydropteroate synthase
答案: 【Amoeba】

4、问题:The following are not suitable as drug targets
选项：
A:Histamine receptor
B:Dihydrofolate reductase
C:Tumor necrosis factor
D:All of the above can be used as drug targets
答案: 【All of the above can be used as drug targets】

5、问题:The following statement about the target is incorrect.
选项：
A:Target theory is the foundation of modern drug discovery
B:Target theory is based on the discovery of drugs through phenotypes
C:Cytokines can also be targets of drug action
D:The druggability of the target is the key to the verification of the target
答案: 【Target theory is based on the discovery of drugs through phenotypes】

6、问题:The research hypothesis of the second-generation anti-tumor drug imatinib is
选项：
A:Philadelphia chromosome aberration and BCR-ABL fusion gene expression
B:Tumor angiogenesis
C:EGFR level overexpression
D:Inactivation of p53 tumor suppressor gene
答案: 【Philadelphia chromosome aberration and BCR-ABL fusion gene expression】

7、问题:Muscarinic acetylcholine receptors belong to
选项：
A:Ligand-gated ion channel receptor
B:G protein coupled receptor
C:Nuclear receptor
D:Receptor tyrosine kinase
答案: 【G protein coupled receptor】

8、问题:The substrate of monoamine oxidase B is
选项：
A:Serotonin
B:Norepinephrine
C:Dopamine
D:Glutamate
答案: 【Dopamine】

9、问题:Clenbuterol, a wheezing drug that belongs to β2 adrenergic receptor, also known as clenbuterol
选项：
A:Agonist
B:Antagonist
C:Inverse agonist
D:Allosteric modulator
答案: 【Agonist】

10、问题:Regarding the druggability statement, which statement is correct:
选项：
A:GPCR-like membrane protein receptors belong to the target type with lower Druggability
B:Refers to whether the target is druggable
C:Low druggability of listed drugs targets
D:High druggability without listed drugs targets
答案: 【Refers to whether the target is druggable】

11、问题:For the requirements of drug targets, what is incorrect is:
选项：
A:The signal pathway where the drug target is located must have a critical impact on the disease
B:The drug target must have a key role in the function of the signal pathway